Ultraschallbasierte Radiofrequency Echographic Multi-Spectrometry-Technologie in der Diagnostik der Osteoporose und der Beurteilung des Frakturrisikos

Zusammenfassung

Die Radiofrequency Echographic Multi-Spectrometry (REMS) ist ein innovatives, strahlenfreies Verfahren zur Bestimmung der Knochenmineraldichte (BMD) und Beurteilung der Knochenstruktur. REMS basiert auf der spektralen Analyse ungefilterter Ultraschallsignale und liefert sowohl klassische BMD-Werte als auch den Fragility Score (FS), der unabhängig von der Knochendichte Hinweise auf die mikrostrukturelle Integrität liefert. In zahlreichen klinischen Studien wurde REMS in verschiedenen Patientenkollektiven untersucht, darunter Diabetes mellitus Typ 2, Arthrose, chronische Nierenerkrankung (CKD), rheumatoide Arthritis, bei jungen Patientinnen mit Anorexia nervosa und Osteogenesis imperfecta. Dieser Review beleuchtet die Funktionsweise von REMS, die Validität im Vergleich zu DXA, die Aussagekraft des Fragility Scores sowie technische und methodische Limitationen. Trotz vielversprechender Ergebnisse ist weitere unabhängige Validierung notwendig.

Abstract

Radiofrequency Echographic Multi-Spectrometry (REMS) is an innovative, radiation-free technique for assessing bone mineral density (BMD), evaluating bone structure and Fracture Risk Prediction. REMS is based on spectral analysis of unfiltered ultrasound signals and provides both conventional BMD values and the Fragility Score (FS), which offers insights into microstructural integrity independently of bone density. Numerous clinical studies have investigated REMS across various patient populations, including those with type 2 diabetes mellitus, osteoarthritis, chronic kidney disease (CKD), rheumatoid arthritis, as well as young female patients with anorexia nervosa and osteogenesis imperfecta. This review highlights the mechanism of REMS, its validity compared to DXA, the clinical relevance of the Fragility Score, and its technical and methodological limitations. Despite promising findings, further independent validation is required.

Schlüsselwörter

Radiofrequency Echographic Multi-Spectrometry (REMS) - Osteoporose - Frakturrisiko - Bne Mineral Density (BMD) - Fragility Score

Keywords

Radiofrequency Echographic Multi-Spectrometry (REMS) - Osteoporosis - Fracture risk - Bone Mineral Density (BMD) - Fragility Score

Publication History

Received: 02 March 2025

Accepted: 30 May 2025

Article published online:
19 August 2025

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